Psychotropic piperidinylmethyl benzodioxans
AssigneeAmerican Home Products Corporation
InventorGary P. Stack
Life of this patent
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Abstract
The compounds ##STR1## in which Z is ##STR2## where R.sup.4 is --H or alkyl; q is one of the integers 0, 1 or 2; Y is H.sub.2 or O; or Z, taken with R.sup.1 forms ##STR3## R.sup.1 is hydrogen or alkyl or combined with Z as described above; R.sup.2 and R.sup.3 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, carbamoyl or sulfonamido or R.sup.2 and R.sup.3, taken together are methylenedioxy, ethylenedioxy or propylenedioxy; m is one of the integers 1, 2 or 3; n is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are antipsychotic, antidepressant and anxiolytic agents useful in relieving the symptoms of these disease states.
Claims1
A method for relieving the symptoms of a psychosis, depression or anxiety which comprises administering to a patient in need thereof, an antipsychotic, antidepressant or anxiolytic amount of a compound of the formula:
- ##STR17## in which Z is ##STR18## where R.sup.4 is --H or alkyl of 1 to 4 carbon atoms;
- q is one of the integers 0, 1 or 2;
- Y is H.sub.2 or O;
- Z, taken with R.sup.1 forms ##STR19## R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms or combined with Z as described above;
- R.sup.2 and R.sup.3 are, independently, hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, aralkoxy of 7 to 12 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, hydroxy, halo, amino, mono- or dialkylamino in which each alkyl group has 1 to 4 carbon atoms, alkanamido of 2 to 6 carbon atoms or sulfonamido or R.sup.2 and R.sup.3, taken together are methylenedioxy, ethylenedioxy or propylenedioxy;
- m is one of the integers 1, 2 or 3;
- n is one of the integers 0 or 1;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.