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US 5,212,169 AGranted
Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
AssigneeG. D. Searle & Co.
InventorsRobert K. Husa, Timothy J. Hagen, E. Ann Hallinan
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Abstract
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Claims22
A compound having a structure of the formula:
- ##STR41## or a pharmaceutically-acceptable salt thereof, wherein:
- X is --NH-- or --CH.sub.2 --;
- Y is
- (1) --CH.sub.2 -- when X is --NH--, and
- (2) --NH-- when X is --CH.sub.2 --;
- R.sup.1 is hydrogen, halogen or --OR.sup.4 ;
- R.sup.4 is hydrogen, alkyl or ##STR42## Z is oxygen, sulfur, --SO--, --SO.sub.2 -- or --NR.sup.5 --;
- R.sup.5 is hydrogen or t-butyloxycarbonyl;
- R.sup.2 is hydrogen, halogen or trifluoromethyl;
- R.sup.3 is hydrogen, halogen, aryl, heteroaryl in which the heteroatoms are selected from oxygen, nitrogen and/or sulfur, or --NR.sup.6 R.sup.7 ;
- R.sup.6 and R.sup.7 are each independently hydrogen or alkyl;
- R.sup.8 is alkyl, aryl or ##STR43## R.sup.9 and R.sup.10 are each independently hydrogen or alkyl, or when taken together form N-morpholino or 4-methyl-N-piperazinyl;
- m and n are each independently integers of from 0 to 3;
- and
- P is 0 or 1, provided that p is not 1 when m is 0.
12 more elements
Dependencies are inferred from the claim text.