Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ACE inhibitor
AssigneeE. R. Squibb & Sons, Inc.
InventorsA. K. Gunnar Aberg, Miguel A. Ondetti
Life of this patent
Estimating the term…
Abstract
A method is provided for rehabilitating or restoring the vasorelaxant action of the endothelium impaired by atherosclerosis and/or hypercholesterolemia, thereby preventing arteriospasm in the coronary arteries using an angiotensin converting enzyme inhibitor such as captopril, fosinopril, ceranapril, enalapril or lisinopril, which may be administered by oral or parenteral dosage forms.
Claims19
A method for rehabilitating or restoring the vasorelaxant action of the coronary endothelium impaired through atherosclerosis and/or hypercholesterolemia, in a mammalian specie, to thereby prevent occurrence of coronary vasospasm, which comprises administering to a mammalian specie in need of such treatment a therapeutically effective amount of an angiotensin converting enzyme inhibitor.
A method for rehabilitating or restoring the vasorelaxant action of the coronary endothelium impaired through atherosclerosis and/or hypercholesterolemia, in a normotensive patient, to thereby prevent occurrence of coronary vasospasm, which comprises administering to a normotensive patient in need of such treatment a therapeutically effective amount of an angiotensin converting enzyme inhibitor.
Dependencies are inferred from the claim text.