3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and derivatives therefrom, processes for the preparation thereof and pharmaceutical compositions containing them
AssigneePoli Industria Chimica S.p.A.
InventorsStefano Poli, Lucio Del Corona, Germano Coppi
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Abstract
3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and the derivatives thereof have valuable immunostimulating, antioxidant, antiradical and antiageing properties. They are prepared by thionating the corresponding 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid derivatives or by condensing 5-thioxo-L-proline with the corresponding L-thiazolidine-4-carboxylic acid derivatives.
Claims6
Compounds of general formula (I) ##STR4## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.6 -C.sub.8 aryl and aralkyl, C.sub.2 -C.sub.10 acyl, C.sub.2 -C.sub.10 straight or branched alkoxyalkyl containing 1-3 oxygen atoms, C.sub.3 -C.sub.8 alkylcarbonylalkyl, and X is --OH, C.sub.1 -C.sub.4 alkoxy, aralkoxy and to the pharmaceutically acceptable salts thereof.
3-L-(5-thioxo-L-propyl)thiazolidine-4-carboxylic acid.
Dependencies are inferred from the claim text.