SRIF-related peptides and uses thereof
AssigneeUniversity of Saskatchewan
InventorsBernard Laarveld, Roy N. Kirkwood, Philip A. Thacker, Lorraine M. Sordillo, mark Redmond
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Abstract
Compositions and methods for modulating SRIF activity as well as enhancing the reproductive performance and immunological function in vertebrates are disclosed. Compositions containing SRIF-related peptides or antibodies thereto can be administered to animals to modulate endogenous SRIF-like activity. The SRIF-related peptides can be linked to a carrier such as ovalbumin, and administered in an Al(OH).sub.3 adjuvant, to enhance the immunogenicity of the SRIF-related peptides.
Claims15
A composition comprising a pharmaceutically acceptable vehicle, an SRIF-related peptide capable of cross-reacting with antisera raised against SRIF-14, said SRIF-related peptide liked to ovalbumin, and an adjuvant comprising Al(OH).sub.3.
A method for enhancing the reproductive efficiency in a vertebrate subject by inducing an immunologic reaction, said method comprising administering to said vertebrate subject a therapeutically effective amount of a composition comprising a pharmaceutically acceptable vehicle and an SRIF-related peptide capable of cross-reacting with antisera raised against SRIF-14, linked to a carrier.
A method for enhancing the immunological function in a vertebrate subject by inducing an immunologic reaction, said method comprising administering to said vertebrate subject a therapeutically effective amount of a composition comprising a pharmaceutically acceptable vehicle and an SRIF-related peptide capable of cross-reacting with antisera raised against SRIF-14, linked to a carrier.
A method for modulating SRIF activity in a vertebrate subject by inducing an immunologic reaction, said method comprising administering to said vertebrate subject a therapeutically effective amount of a composition comprising a pharmaceutically acceptable vehicle and an SRIF-related peptide capable of cross-reacting with antisera raised against SRIF-14, linked to a carrier.
A method for enhancing phagocytic cell function in a vertebrate subject by inducing an immunologic reaction, said method comprising administering to said vertebrate subject a therapeutically effective amount of a composition comprising a pharmaceutically acceptable vehicle and an SRIF-related peptide capable of cross-reacting with antisera raised against SRIF-14, linked to a carrier.
Dependencies are inferred from the claim text.