Preparation for treating complications in diabetes
AssigneeAkzo N.V.
InventorRobby Huisman
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Abstract
Preparation for preventing or combating complications in diabetes, characterized in that it comprises: (a) insulin or a salt or complex thereof, and (b) a peptide of the general formula I: H-L-Met(X)-L-Glu-L-His-L-Phe-D-Lys-L-Phe-Y or a salt or a N-acyl derivative thereof, wherein Met(X) represents the amino acid radical Met, Met(O) or Met(O.sub.2), Y represents the group Gly-Z or Z, and Z represents the hydroxyl group, an esterified hydroxyl group or a substituted or unsubstituted amino group.
Claims7
A preparation for treating sensory diabetic neuropathies, comprising (a) from about 10 to about 100 international units of insulin per milliliter of preparation and (b) from about 0.35 to about 6.5 milligrams of a peptide of the formula:
- H-L-Met(O.sub.2)-L-Glu-L-His-L-Phe-D-Lys-L-Phe-OH
- or a salt thereof per milliliter of preparation.
A method of treating sensory complications in diabetes comprising administering to a diabetic patient in need of said treatment from about 0.35 to about 6.5 milligrams of the peptide of the formula:
- H-L-Met(O.sub.2)-L-Glu-L-His-L-Phe-L-Phe-D-Lys-L-Phe-OH.
Dependencies are inferred from the claim text.