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US 5,212,078 AGranted
Process for producing a lactone
AssigneeInternational Flavors & Fragrances Inc.
InventorsMohamad I. Farbood, James A. Morris, Arthur E. Downey
Life of this patent
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Abstract
Described is a microbiological method for producing the lactone, sclareolide having the structure: ##STR1## and a diol having the chemical structure: ##STR2## using a sclareol derivative having one of the structures: ##STR3## wherein a combination of two or more of the compounds as a substrate and using one of the microorganisms: Cryptococcus albidus, ATCC 20918 Bensingtonia ciliata, ATCC 20919 Cryptococcus laurentii, ATCC 20920 or Cryptococcus albidus, ATCC 20921.
Claims7
A process for preparing a lactone compound having the structure:
- ##STR67## which comprises cultivating a microorganism selected from the group consisting of:
- Cryptococcus albidus, ATCC 20918;
- and
- Cryptococcus albidus, ATCC 20921
- to produce said lactone in a recoverable quantity upon the transformation of a substrate comprising a carbon source and in addition, at least one compound selected from the group consisting of:
- ##STR68## under aerobic conditions in an aqueous nutrient medium containing one or more compounds from said group and an additional carbon source wherein:
- (i) the pH of the reaction mass is between about 2.5 and about 9.0;
- (ii) the temperature of the reaction mass is between about 12.degree. C. and about 33.degree. C.;
- and
- (iii) the substrate concentration is between about 0.1 grams per liter up to about 130 grams per liter
- and recovering said lactone.
8 more elements
Dependencies are inferred from the claim text.