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AssigneeThe Regents of the University of California
InventorsMark D. Bednarski, Carolyn R. Bertozzi, Jon O. Nagy
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Compositions and methods for the inhibition and prevention of pathogenic infection and neoplastic disease are provided. The compositions include hybrid molecules having a binding moiety and an effector moiety joined by a linker region. When administered to a host, the binding moiety, such as a carbohydrate, attaches to a receptor, such as a conserved lectin receptor on the pathogen or neoplastic cell, and the effector moiety provides an invariant antigenic determinant for eliciting or modulating an immune response. The effector moiety may also be a drug or other compound which inhibits growth of a bound pathogen or cell. Compositions comprising the hybrid molecule in a suitable pharmaceutical carrier are also provided.
A method for introducing a heterologous antigenic determinant to the surface of a pathogen or cell, said method comprising exposing the pathogen or cell to hybrid molecules having a carbohydrate binding moiety which binds specifically to a conserved pathogen or cellular receptor and an effector moiety which includes the heterologous antigenic determinant, wherein the heterologous antigenic determinant is exposed when the binding moiety is bound to the receptor and wherein the hybrid molecule has a molecular weight below about 3 kD.
A method for introducing a heterologous antigenic determinant to a lectin on the surface of a pathogen, said method comprising:
Dependencies are inferred from the claim text.