Pharmaceutical preparation for administration by percutaneous absorption and a method for their manufacture
AssigneesChugai Seiyaku Kabushili Kaisha, Sekisui Kagaku Kogyo Kabushiki Kaisha
InventorsMasato Azuma, Toshihiro Inoue, Yasuaki Kawano
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Abstract
A pharmaceutical preparation for percutaneous absorption comprising a base material and fine crystals of Nicorandil and/or salts of Nicorandil that are evenly distributed throughout said base material and that have a mean diameter of 2 .mu.m or more, and a method for preparing the same.
Claims42
A pharmaceutical preparation for percutaneous absorption comprising a base material which is not compatible with Nicorandil and Nicorandil which may be in a free form or in the form of a salt thereof and is evenly distributed throughout said base material, wherein said Nicorandil exists as fine crystals having a mean diameter of between 2 and 50 .mu.m whereby the stability of Nicorandil in said preparation during storage is greatly improved.
A method for the manufacture of a pharmaceutical preparation for the percutaneous absorption comprising a base material which is not compatible with Nicorandil and Nicorandil which may be in a free form or in the form of a salt thereof and is evenly distributed throughout said base material, wherein said Nicorandil exists as fine crystals having a mean diameter of between 2 and 50 .mu.m including:
- dissolving the Nicorandil and/or its salts in a solvent that is a good solvent for said Nicorandil;
- and
- dissolving the base material in a solvent that is a poor solvent for said Nicorandil;
- mixing these two solutions to give a solution of a mixture that contains precipitated crystals of Nicorandil and/or its salts with a mean diameter of 2-50 .mu.m;
- and
- substantially removing said good solvent and said poor solvent from said solution of the mixture.
Dependencies are inferred from the claim text.