Method for disinfecting red blood cells, blood products, and corneas
AssigneeUniversity of Southern California
InventorAlan I. Rubinstein
Life of this patent
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Abstract
A method to inactivate viruses or to disinfect blood products, for instance units of red blood cells, wherein a disinfectant or virus inactivating chemical is made isotonic or nearly isotonic, and wherein the red blood cells are exposed to isotonic disinfectant to inactivate any agent which may be present, for example HIV-1 virus which causes AIDS. The method may also be applied to plasma fractions and corneas.
Claims32
A method for treating blood products and tissue products to inactivate viruses and microorganisms contained therein, said method comprising the steps of:
- mixing a blood product or a tissue product with a disinfectant composition for a sufficient time to inactivate said viruses, said disinfectant composition comprising:
- a disinfectant selected from the group consisting of sodium chlorite and an acid, a water soluble chlorine dioxide liberating compound and an acid, and chlorine dioxide, and
- an aqueous diluent, said diluent consisting essentially of water and a solute which, when the solute is at the proper concentration, the disinfectant composition is substantially isotonic with blood;
- and
- separating the disinfectant from the blood product or tissue product, said blood product or tissue product being substantially viable for diagnostic or therapeutic use.
A method for treating red blood cells to inactivate viruses contained therein, said method comprising the steps of:
- mixing said red blood cells with a disinfectant composition for a sufficient time to inactivate said viruses, said disinfectant composition comprising:
- a sufficient amount of a disinfectant to inactivate said virus, said disinfectant comprising sodium chlorite and an acid;
- and
- a diluent, said diluent consisting essentially of water and a solute which, when the solute is at the proper concentration, the disinfectant composition is substantially isotonic with blood;
- and
- separating the disinfectant from the red blood cells, said red blood cells being substantially viable for diagnostic or therapeutic use.
A method for treating red blood cells to inactivate the AIDS virus contained therein, said method comprising the steps of:
- mixing the red blood cells with a disinfectant composition for a sufficient time to inactivate said AIDS virus, said disinfectant composition comprising:
- a disinfectant selected from the group consisting of sodium chlorite and an acid, and
- an aqueous diluent, said diluent consisting essentially of water and a solute which, when the solute is at the proper concentration, the disinfectant composition exerts an osmotic pressure sufficient to prevent the hemolysis of said red blood cells;
- separating the disinfectant from said red blood cells, said red blood cells being substantially viable for diagnostic or therapeutic use.
Dependencies are inferred from the claim text.