Analytical method and apparatus using capillary tube

An apparatus for analysis using a capillary tube which comprises:

• a capillary tube having a sample receiving position such that a sample can flow downstream through said capillary tube from said sample receiving position,
• capillary holders which hold the capillary tube at two spaced positions thereby forming a specific zone between said two spaced positions which can vibrate, said specific zone being positioned downstream of said sample receiving position,
• an irradiation device which irradiates the specific zone of the capillary tube with a periodically intensity-modulated beam or a periodical pulse beam, and
• a detection device which detects a mechanical vibration of the capillary tube in the specific zone, said mechanical vibration being induced in correspondence to the modulated frequency or intervals of irradiation time of the pulse beam.

An apparatus for analysis of a sample, comprising:

• capillary tubing through which a sample may flow from a first end to a second end, said capillary tubing having a separation zone in which analytes in a sample can be separated downstream of said first end, and a detection zone downstream of said separation zone and upstream of said second end;
• capillary tubing holders holding said capillary tubing at two spaced positions defining said detection zone therebetween, wherein said capillary tubing holders hold said capillary tubing such that said detection zone is under tension;
• separation means for separating said analytes in said separation zone;
• irradiation means for irradiating a portion of said detection zone with a periodically intensity-modulated excitation beam or a periodical pulse-like excitation beam;
• and
• detection means for detecting information based on mechnical vibration of said capillary tubing in said detection zone caused by periodic heat fluctuation of analytes in said detection zone due to absorption of said excitation beam by said analytes.