Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
AssigneeThe United States Government as represented by the Secretary of the Department of Health and Human Services
InventorsYoshihiko Yamada, Makoto Sasaki, Hynda K. Kleinman, George R. Martin
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Abstract
The present invention relates to peptides and derivatives thereof having laminin-like activity. The invention further relates to pharmaceutical compositions containing these peptides, to antibodies effective against these peptides, and to vectors containing a DNA sequence of cDNA coding for the A chain of laminin. The peptides of the invention may be used to treat diseases such as cancer.
Claims17
Peptides and derivatives thereof having laminin A-like activity selected from the group consisting of:
- (i) KCQAGTFALRGDNPQG,
- (ii) CSKCQAGTFALR,
- (iii) XFALRGDNPQG,
- (iv) XSRARKQAASIKVAVSADR,
- (v) XRKQAASIKVAVS,
- (vi) XIKVAVSADR,
- (vii) XSRNLSEIKLLISRARK
- (viii) GLWNYIEREGKC,
- (ix) KPLKTLEENLSRNLSEI,
- (x ) DRLKPLKTLEENLSRNLSEI,
- (xi) XGQIKKSPAVKVTHFKG,
- (xii) XGQIKKSPAVKVT, and
- (xiii) CIRAYQPQTSSTNYNTLTIL
- wherein the X group is an amino acid which is not present in the A chain but is used in coupling the peptide to other materials.
Dependencies are inferred from the claim text.