Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles
AssigneeUniversity of South Florida
InventorsGeorge R. Newkome, Charles N. Moorefield
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Abstract
The bis-homotris compounds 4-amino-4-[1-(3-hydroxy-propyl)]-1,7-heptanediol and 4-[1-(3-aminopropyl)]-4-[1-(3-hydroxypropyl)]-1, 7-heptanediol, and organic synthetic methods for their preparation are described. Unique multifunctional aminotriols, as well as their percursors, quaternary nitroalkanes are disclosed as building blocks for unimolecular micelles, as well as new series of cascade polymers. The quaternary nitro compounds which are disclosed allow the synthesis of a new aminotriol containing a quaternary carbon.
Claims5
A method of preparing a compound of the Formula(A) ##STR9## by the steps of:
- 1) forming a nitroalkylnitrile of the Formula(B) ##STR10## 2) hydrolyzing under acid conditions the nitrile to the corresponding tricarboxylic acid having the Formula(C) ##STR11## 3) reducing the tricarboxylic acid to a nitrotriol;
- and 4) reducing the nitro portion of the nitrotriol to derive the bishomotris of Formula(A) by a non-tris derivative route.
Dependencies are inferred from the claim text.