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AssigneeInstitute of Nuclear Energy Research
InventorsLee Te-Wei, Ting Gann, Su Chang-Shinn, Chyi Shyh-Yi
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A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
A method for synthesis of 2-alkoxyisobutylisonitrile using isobutylene as the starting material, said method comprising a haloalkoxylation of said isobutylene to give 2-alkoxyisobutylhalide, converting the 2-alkoxyisobutylhalide to 2-alkoxyisobutylamine, and under basic conditions reacting said 2-alkoxyisobutylamine with chloroform to produce 2-alkoxyisobutylisonitrile, wherein the product 2-alkoxyisobutylisonitrile has a general formula ##STR18## wherein R is an alkyl group having 1-4 carbon atoms.
Dependencies are inferred from the claim text.