Back to results
US 5,210,263 AGranted
Inositol phosphate analogs and methods for their use
AssigneesUniversity of Pittsburgh, Mayo Foundation for Medical Education and Research
InventorsAlan P. Kozikowski, Garth Powis
Life of this patent
Estimating the term…
Abstract
The present invention provides novel inositol phosphate analogs and a method for their use for detecting the phosphatidylinositol cycle-dependent calcium of a cell.
Claims5
A compound represented by the general formula I:
- ##STR5## wherein:
- R.sup.1 is selected from the group consisting of --OP).sub.3 H.sub.2 and --OPO.sub.3.sup..dbd. ;
- each R.sup.2 is independently selected from the group consisting of C.sub.1-8 linear or branched alkyl, --F, --Cl, --Br. --I, NH.sub.2, --N.sub.3, --NHOH, --NHNH.sub.2, --CN, --NC, --SH, --SeH, --H, and each R.sup.2 can be joined to form .dbd.NOH, .dbd.NNH.sub.2,
- each R.sup.3 is independently selected from the group consisting of --OPO.sub.3 H.sub.2, --OPO.sub.3.sup..dbd. and --OH;
- with the proviso that at least one of said R.sup.2 is H except when:
- (i) each R.sup.2 is joined to form .dbd.NOH, .dbd.NNH.sub.2, .dbd.O or .dbd.S;
- and
- (ii) R.sup.2 is --F, --Cl, --Br, or --I, then the other R.sup.2 is --F, --Cl, --Br, --I, or H.
5 more elements
Dependencies are inferred from the claim text.