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US 5,210,258 AGranted
Optically active alpha-naththylalkyl ketones
AssigneeSyntex Pharmaceuticals International Ltd.
InventorGeorge C. Schloemer
Life of this patent
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Abstract
Optically active naphthyl alpha-substituted alkyl ketones, are a class of ketones useful as intermediates in the production of optically active alpha-naphthylalkanoic acids which exhibit anti-inflammatory, analgesic and anti-pyretic activity.
Claims21
A material comprising a compound of the formula:
- ##STR48## having an optical purity of greater than 90%, wherein Ar is 6-methoxy-2-naphthyl, R.sub.1 is alkyl or cycloalkyl and Z is halogen, hydroxy, acetoxy, benzoyloxy, dihydropyranyloxy, trialkylsiloxy or a group of the formula:
- ##STR49## wherein R.sub.2 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl or aralkyl.
A material consisting essentially of a single stereoisomer of a compound of the formula:
- ##STR50## wherein Ar is 6-methoxy-2-naphthyl, R.sub.1 is alkyl or cycloalkyl and Z is halogen, hydroxy, acetoxy, benzoyloxy, dihydropyranyloxy, trialkylsiloxy or a group of the formula:
- ##STR51## wherein R.sub.2 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl or aralkyl.
Dependencies are inferred from the claim text.