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US 5,210,230 AGranted
Lignan process
AssigneeMerck & Co., Inc.
InventorJoseph F. Payack
Life of this patent
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Abstract
A three-step process is described for the preparation of a lignan of the formula ##STR1## This lignan is useful as an intermediate for the preparation of anti-asthmatic pyranylphenyl hydroxyalkylnaphthoic acids.
Claims4
A process for preparing the compound of Formula I:
- wherein:
- R.sup.8 is halogen, lower alkyl, or lower alkoxy;
- .circle.Ar is phenyl or 1- or 2-naphthyl;
- and
- m is 0, 1, or 2;
- which comprises:
- a) reacting a compound of formula 2:
- ##STR12## with a strong base in an ethereal solvent, adding butenolide thereto, then quenching with 3-benzyloxybenzaldehyde all at -100.degree. to 0.degree. C., to produce a compound of formula 3 ##STR13## b) reacting compound 3 with a strong acid in the presence of a cation scavenger at 0.degree.-150.degree. C. to produce said compound of formula I.
5 more elements
Dependencies are inferred from the claim text.