Immunosuppressive compounds
AssigneesFisons Limited, Fujisawa Pharmaceutical Co., Ltd.
InventorsHirokazu Tanaka, Martin E. Cooper, David K. Donald
Life of this patent
Estimating the term…
Abstract
Compounds of formula I, ##STR1## wherein R.sup.1 represents H, OH, protected OH or alkoxy; R.sup.2 represents H; R.sup.3 represents O or (H,OH); R.sup.4 represents methyl, ethyl, propyl or allyl; R.sup.5 represents OH, protected OH or alkoxy; R.sup.6 represents OH; R.sup.7 represents OH, alkoxy or NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 independently represent H, alkyl or aryl; in addition, R.sup.1 and R.sup.2 may together represent a second bond between the carbon atoms to which they are attached; and R.sup.6 and R.sup.7 may together represent O; and pharmaceutically acceptable salts thereof; are useful inter alia as immunosuppressive agents. The invention also provides the novel compounds of formula I.
Claims7
A compound of formula I, ##STR5## wherein R.sup.1 represents H, OH, protected OH or alkoxy;
- R.sup.2 represents H;
- R.sup.3 represents O or (H,OH);
- R.sup.4 represents methyl, ethyl, propyl or allyl;
- R.sup.5 represents OH, protected OH or alkoxy;
- R.sup.6 represents OH;
- R.sup.7 represents OH, alkoxy or NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 independently represent H, alkyl or aryl;
- in addition, R.sup.1 and R.sup.2 may together represent a second bond between the carbon atoms to which they are attached;
- and
- R.sup.6 and R.sup.7 may together represent O;
- provided that when R.sup.1 and R.sup.5 each represent OH, R.sup.2 represents H, R.sup.3 represents (H,OH) and R.sup.4 represents allyl, then R.sup.6 and R.sup.7 do not together represent O;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.