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US 5,210,224 AGranted
Process for preparing lankacidin carbamate derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsAkio Miyake, Tatsuhiko Kawai
Life of this patent
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Abstract
A process for preparing a lankacidine carbamate derivative of the formula ##STR1## or a salt thereof, by the reaction of a lankacidine 8-substituted carbonate with an amine, wherein R.sub.1 is a hydroxy group or an alkanoyloxy group; and R.sub.2 and R.sub.3 are each a hydrogen atom, an optionally substituted lower alkyl group, a cycloalkyl group or a phenyl group; or R.sub.2 and R.sub.3 together with an adjacent nitrogen atom to which they bond form an optionally substituted heterocyclic group.
Claims3
A process for preparing a compound represented by the formula [III]:
- ##STR20## wherein R.sub.1 is a hydroxy group or an alkanoyloxy group;
- and R.sub.2 and R.sub.3 are each (1) a hydrogen atom or (2) a methyl group which is unsubstituted or is substituted by pyridyl;
- or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond form a piperazino group which is unsubstituted or is substituted by methyl, hydroxymethyl, or pyridyl, or a salt thereof, comprising reaction a compound represented by the formula [I]:
- ##STR21## wherein R.sub.1 has the same meaning as above;
- X is chlorine;
- and Y is methyl, with a compound represented by the formula [II]:
- ##STR22## wherein R.sub.2 and R.sub.3 have the same meaning as above.
4 more elements
Dependencies are inferred from the claim text.