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US 5,210,208 AGranted
Disubstituted aryl compounds exhibiting selective leukotriene B4 antagonist activity
AssigneeRhone-Poulenc Rorer Pharmaceuticals Inc.
InventorsFu-Chih Huang, Wan K. Chan, Charles A. Sutherland, Robert A. Galemmo, Jr., Michael N. Chang
Life of this patent
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Abstract
Monocyclic and bicyclic aryl ring compounds having selective LTB.sub.4 properties and comprising two ring substituents, the first substituent comprising a lipophilic group and a terminal carboxylic acid or derivative group, and the second substituent comprising an amido group, therapeutic compositions and methods of treatment of disorders which result from LTB.sub.4 activity using the mono- and bicyclic aryl compounds are disclosed.
Claims20
A compound of the formula ##STR25## where:
- ##STR26## where R' is hydrogen or lower alkyl (having about 1 to about 6 carbon atoms) and R" is hydrogen, lower alkyl (having about 1 to about 6 carbon atoms) or lower alkoxy (having about 1 to about 6 carbon atoms);
- ##STR27## is selected from (CHR.sub.2).sub.d --E where d is 0-4, --(CR.sub.2 .dbd.CR.sub.2).sub.x --E where x is 1-2, --O--(CHR.sub.2).sub.d --E where d is 1-3, --(CHR.sub.2).sub.d --CR.sub.2 .dbd.CR.sub.2 --E where d is 1-3 and --O--(CHR.sub.2).sub.d --CR.sub.2 .dbd.CR.sub.2 --R where d is 1-3,
- R.sub.1 is hydrogen;
- R.sub.2 is hydrogen, lower alkyl (having about 1 to about 6 carbon atoms) and at least one of R.sub.2 is selected from ##STR28## where g is 0-3, R' is hydrogen or lower alkyl (having about 1 to about 6 carbon atoms) and R" is hydrogen, lower alkyl (having about 1 to about 6 carbon atoms) or lower alkoxy (having about 1 to about 6 carbon atoms);
- and ##STR29## E is --COOH or;
- or an isomer or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.