1,3-oxazolyl substituted biphenyl
AssigneeAbbott Laboratories
InventorsHoward E. Morton, Biswanath De, Daniel J. Kerkman
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Abstract
The present invention relates to a process for the preparation of a compound of the formula: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, lower alkenyl, lower alkynyl, cycloalkyl and cycloalkylalkyl; R.sub.2 is selected from the group consisting of hydrogen, loweralkyl, loweralkoxy-substituted loweralkyl, halogen and loweralkoxy; R.sub.3 is selected from hydrogen, loweralkyl, and halogen; R* and R** are independently selected from loweralkyl and P.sub.1 is hydrogen or an nitrogen-protecting group; or an acid addition salt thereof.
Claims6
A compound of the formula:
- ##STR6## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 to C.sub.7 loweralkyl, C.sub.1 to C.sub.7 loweralkoxy-substituted C.sub.1 to C.sub.7 loweralkyl, C.sub.2 to C.sub.10 lower alkenyl, C.sub.2 to C.sub.10 lower alkynyl, C.sub.3 to C.sub.7 cycloalkyl and C.sub.3 to C.sub.7 cycloalkyl substituted C.sub.1 to C.sub.7 loweralkyl;
- R.sub.2 is selected from the group consisting of hydrogen, C.sub.1 to C.sub.7 loweralkyl, C.sub.1 to C.sub.7 loweralkoxy-substituted C.sub.1 to C.sub.7 loweralkyl, halogen and C.sub.1 to C.sub.7 loweralkoxy;
- R.sub.3 is selected from hydrogen, C.sub.1 to C.sub.7 loweralkyl, and halogen;
- R* and R** are independently selected from C.sub.1 to C.sub.7 loweralkyl and P.sub.1 is hydrogen or an nitrogen-protecting group;
- or an acid addition salt thereof.
The compound of the formula:
- ##STR7## wherein P.sub.1 is hydrogen or a nitrogen protecting group;
- and an acid addition salt thereof.
The compound of the formula:
- ##STR8## or an acid addition salt thereof.
The compound of the formula:
- ##STR9## wherein Tr is trityl.
Dependencies are inferred from the claim text.