Back to results
US 5,210,204 AGranted
Biphenyl oxadiazoles and thiadiazoles as angiothesin II antagonists
AssigneeWarner-Lambert Company
InventorsDavid T. Connor, Catherine R. Kostlan
Life of this patent
Estimating the term…
Abstract
Heterocyclic methyl derivatives of biphenyl oxadiazoles and thiadiazoles are described, as well as methods for the preparation of said derivatives and pharmaceutical compositions of the same, which are useful as antagonists of the angiotensin II enzyme and thus useful in treating hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
Claims11
A compound of the formula ##STR10## wherein Ra is independently hydrogen, lower alkyl, lower alkoxy, or halo;
- X is oxygen or sulfur;
- Y is OH or SH, and
- Ar is selected form the group consisting of ##STR11## wherein X' is oxygen or sulfur;
- R.sub.1 and R.sub.1 ' are each independently lower alkyl;
- R.sub.2 is CH.sub.2 OH, CHO, or CO.sub.2 R.sub.4 ;
- R.sub.3 is hydrogen, halo, or a pyrrole group attached at the nitrogen atom and unsubstituted or substituted by lower alkyl, and R.sub.4 is hydrogen or lower alkyl;
- a tautomer thereof and a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.