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US 5,210,092 AGranted
Angiotensin II antagonizing heterocyclic derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTeruo Oku, Hiroyuki Setoi, Hiroshi Kayakiri, Shigeki Satoh, Takayuki Inoue, Yuki Saitoh, Akio Kuroda, Hirokazu Tanaka
Life of this patent
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Abstract
The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc.
Claims9
A compound of the formula:
- ##STR30## wherein R.sup.1 is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino,
- R.sup.2, R.sup.3 and R.sup.4 are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, mono or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl, or optionally esterified carboxy;
- or
- R.sup.2 and R.sup.3 are linked together to form 1,3-butadienylene,
- R.sup.5 is hydrogen or an imino-protective group,
- A is lower alkylene,
- Q is CH or N,
- X is N or CH,
- Y is NH, O or S, and ##STR31## is 1H-imidazol-1-yl which is condensed at the 4,5-positions with an aromatic ring, which may have lower alkyl, halogen, lower alkoxy, hydroxy(lower)alkyl or optionally esterified carboxy substituents,
- provided that Y=NH when X=CH, and a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.