Muramyl dipeptide derivatives
AssigneeSandoz Ltd.
InventorsLouis Chedid, Peter Dukor, Pierre Lefrancier, Peter Stutz
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Abstract
The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly useful as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy group(s) in protected form.
Claims7
The forms of the compound of formula I ##STR5## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration.
Dependencies are inferred from the claim text.