Aerosol compositions
AssigneeBeecham Group Limited
InventorsSusan E. Brobyn, Robert D. Mackie
Life of this patent
Estimating the term…
Abstract
Aerosol compositions for topical application, conferring a cooling effect on the body and suitable for use in the alleviation of pain, such as muscular or rheumatic pain, which compositions do not contain environmentally unacceptable chlorofluorocarbons but satisfy safety guidelines on flammability, and comprise an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from 10.degree. to 40.degree. C. and an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from -45.degree. to -10.degree. C., in a ratio of from 3 to 7 parts by weight of the higher boiling component (serving primarily as a coolant) per part by weight of the lower boiling component (serving primarily as a propellant).
Claims14
An aerosol composition comprising:
- (i) isopentane, n-pentane, diethyl ether or methylene chloride, or mixtures of any two or more thereof having a boiling point within the range of from 10.degree. C. to 40.degree. C., and
- (ii) dimethyl ether, a hydrocarbon or a partially hydrogenated chlorofluorocarbon, or mixture of any two or more thereof having a boiling point within the range of from -45.degree. C. to -10.degree. C., or having a vapor pressure within the range of from 15 to 115 psig (pounds per square inch;
- at 20.degree. C.);
- in a ratio of from 2.5 to 6 parts by volume of component (i) per 1 part by volume of component (ii) (or from 3 to 7 parts by weight of component (i) per 1 part by weight of component (ii)).
A pharmaceutical composition for topical application to the skin comprising a substance that is pharmaceutically active when topically applied to the skin in an amount up to 15% by volume or up to 20% by weight of the total composition, and
- (i) an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from 10.degree. C. to 40.degree. C., and
- (ii) an organic substance, other than a chlorofluorocarbon, having a boiling point within the range of from -45.degree. to -10.degree. C., or having a vapor pressure within the range of from 15 to 115 psig (pounds per square inch;
- at 20.degree. C.);
- in a ratio of from 2.5 to 6 parts by volume of component (i) per 1 part by volume of component (ii) (or from 3 to 7 parts by weight of component (i) per 1 part by weight of component (ii)).
An aerosol composition comprising 67.77% by weight of isopentane, 14.41% by weight of dimethylether, 6.82% by weight of isopropanol, 10.00% by weight of glycol salicylate, and 1.00% by weight of menthol.
Dependencies are inferred from the claim text.