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US 5,209,853 AGranted
Liquid chromatography
AssigneeU.S. Philips Corporation
InventorsRoderick J. Lynch, Gregory J. Measures, Charles V. Perkins
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Abstract
A method of analysis by liquid chromatography and liquid chromatograph apparatus are disclosed. The method and apparatus are arranged to enable a chromatographer to locate an optimum solvent composition for a particular analysis. A display is produced which shows simltaneously a contour map of chromatogram quality across an isoeluotropic plane and a predicted chromatogram corresponding to a selected point on the isoeluotropic plane.
Claims10
A method of optimizing solvent compositions for the analysis of a sample by liquid chromatography comprising the steps of:
- (a) defining a plurality of solvent compositions,
- (b) performing a plurality of chromatographic analyses using the defined solvent compositions,
- (c) storing the chromatograms produced,
- (d) labeling each peak in each of said chromatograms
- (e) modelling the retention time of each peak with changing solvent composition,
- (f) modelling a quality of the chromatograms across a surface and producing and displaying the quality across the surface,
- (g) selecting a point on the surface,
- (h) displaying a predicted chromatogram corresponding to the selected point.
5 more elements
Dependencies are inferred from the claim text.