Blood cryopreservation container
OwnerJoseph D. Irr, John D. Walker +2inventors
InventorsJoseph D. Irr, John D. Walker, George F. Dunn, Jr., Viet X. Nguyen
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Abstract
This invention relates to containers for the cryopreservation of mammalian cells and particularly for the long-term freezing of red blood cell. This invention also relates to methods of manufacturing such containers.
Claims13
In a container comprising a body of a laminate film (3) having a layer of a polyimide film facing the outside of the container and a fluoropolymer film layer facing the inside of the container, a filling port (2), and a transfusion port sealed between said laminate film (3), the improvement comprising the transfusion port being incorporated into a transfusion port tab insert (1) comprising:
- (a) a fluoropolymer film layer (15) being bonded to the fluoropolymer film layer of (3) which is facing the inside of the container;
- (b) a laminate film (10) having a polyimide layer and a fluoropolymer film layer, the fluoropolymer film layer of (10) being bonded to the fluoropolymer film layer (15);
- (c) at least one strip of piercable spike-through material (12) made of a thermoplastic polyester elastomer film, the spike-through material (12) being bonded to the polyimide layer of (10), said spike-through material having a high degree of resilience;
- and
- (d) a strip of material (11) being non-bondable to the spike-through material (12);
- wherein (12), (10), and (15) are bonded thereby forming peripheral seals (13) made on each side of the tab insert (1), such that the spike-through material (12) is sealed to itself, except to the extent that the non-bondable strip of material (11) prevents such bonding, and the film (10) is sealed to the spike-through material (12) and optionally an additional seal is made across the width of the spike port tab insert (1) perpendicular to the peripheral seals (13).
In a container comprising a body of a laminate film (3) having a layer of a polyimide film facing the outside of the container and a fluoropolymer film layer facing the inside of the container, a filling port (2), and a transfusion port sealed between said laminate film (3), the improvement comprising the transfusion port being incorporated into a transfusion port tab insert (1) comprising:
- (a) a laminate film (10) having a polyimide layer and a fluoropolymer film layer, the fluoropolymer film layer of (10) being bonded to the fluoropolymer film layer of (3) which is facing the inside of the container;
- (b) at least one strip of piercable spike-through material (12) made of a thermoplastic polyester elastomer film, the spike-through material (12) being bonded to the polyimide layer of (10), said spike-through material having a high degree of resilience;
- and
- (c) a strip of material (11) being non-bondable to the spike-through material (12);
- wherein (12) and (10) are bonded thereby forming peripheral seals (13) made on each side of the tab insert (1), such that the spike-through material (12) is sealed to itself, except to the extend that the non-bondable strip of material (11) prevents such bonding, and the film (10) is sealed to the spike-through material (12) and optionally an additional seal is made across the width of the spike port tab insert (1) perpendicular to the peripheral seals (13).
Dependencies are inferred from the claim text.