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US 5,208,381 AGranted
Method for the manufacture of carotinoids and novel intermediates
AssigneeHoffmann-La Roche Inc.
InventorKarl Meyer
Life of this patent
Estimating the term…
Abstract
Phosphonium salts of the formula ##STR1## wherein A signifies aryl and Y.sup.- signifies C.sub.1 -C.sub.6 -alkanoate or hydroxytrifluoroborate, as well as their manufacture from 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol with a triarylphosphine and with a C.sub.1 -C.sub.6 -alkanoic acid or a boron trifluoride etherate and, if desired after conversion into the phosphonium salt of a strong acid, further reaction to give lycopene.
Claims3
A method for the manufacture of a 3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl phosphonium salt of a strong acid comprising
- a) reacting 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol with triarylphosphine and a compound selected from the group consisting of C.sub.1-6 alkanoic acid and boron trifluoride etherate to produce a compound of the formula ##STR4## wherein R is aryl and Y.sup.- is C.sub.1-6 -alkanoate or hydroxytrifluoroborate and
- b) reacting the compound of formula I with a strong acid.
Dependencies are inferred from the claim text.