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US 5,208,353 AGranted
Intermediates for preparing epoxy esters
AssigneeSmithKline Beecham Corporation
InventorsJoseph R. Flisak, Paul G. Gassman, Ivan Lantos, Wilford L. Mendelson
Life of this patent
Estimating the term…
Abstract
This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
Claims12
A chemical compound having the formula:
- ##STR8## wherein R.sub.1 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B:
- a is 0 or 1;
- b is 3 to 14;
- c is 0 or 1;
- L and T are independently oxygen or CH.sub.2 ;
- B is C.sub.1-4 alkyl, trifluoromethyl, furanyl, thienyl, cyclohexyl or phenyl, optionally monosubstituted with Br, Cl, CF.sub.3, C.sub.1-4 alkoxy, or C.sub.1-4 alkyl;
- R.sub.2 and A are independently selected from H, CF.sub.3, C.sub.1-4 alkyl, halogen or NO.sub.2 ;
- or R.sub.1 is H and R.sub.2 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B, wherein a, b, c, L, T and B are as defined above;
- and
- R3 is phenyl or naphthyl unsubstituted or substituted by one or two halogen, Cl-4alkyl, Cl-4alkoxy or trifluoromethyl groups.
7 more elements
A chemical compound having the formula:
- ##STR9## wherein R.sub.1 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B;
- a is 0 or 1;
- b is 3 to 14;
- c is 0 or 1;
- L and T are independently oxygen or CH.sub.2 ;
- B is C.sub.1-4 alkyl, trifluoromethyl, furanyl, thienyl, cyclohexyl or phenyl, optionally monosubstituted with Br, Cl, CF.sub.3, C.sub.1-4 alkoxy, or C.sub.1-4 alkyl;
- R.sub.2 and A are independently selected from H, CF.sub.3, C.sub.1-4 alkyl, halogen or NO.sub.2,;
- or R.sub.1 is H and R.sub.2 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B, wherein, a, b, c, L, T and B are as defined above;
- and
- R.sub.3 is phenyl or naphthyl unsubstituted or substituted by one or two halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl groups.
7 more elements
Dependencies are inferred from the claim text.