Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5.alpha.-epoxymorphinans
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsBrian R. de Costa, Michael J. Iadarola, Kenner C. Rice, Richard B. Rothman, Karen F. Berman
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Abstract
The present invention is directed to radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5.alpha.-epoxymorphinans, intermediates for producing the same, and a process for the preparation and methods of detecting opioid receptors. The radioimaging agent of the present invention has the following formula: ##STR1## wherein I is selected from the group consisting of .sup.123 I and .sup.125 I; and where R is alkyl, cycloalkylloweralkyl or allyl.
Claims5
A radioimaging agent having the formula:
- ##STR5## wherein I is selected from the group consisting of .sup.123 I and .sup.125 I;
- and where R is alkyl having from about 1 to 6 carbon atoms, cycloalkylloweralkyl or allyl.
A compound having the formula:
- ##STR8## wherein R is alkyl having from about 1 to 6 carbon atoms, cycloalkylloweralkyl or allyl.
Dependencies are inferred from the claim text.