Process for the preparation of aminopyrimidines
AssigneeHoechst Aktiengesellschaft
InventorsStephen Lachhein, Hilmar Mildenberger
Life of this patent
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Abstract
2-Aminopyrimidines of the formula I ##STR1## in which X and Y are O or S and R.sup.1 and R.sup.2 independently of one another are lower alkyl, alkoxyalkyl or haloalkyl, are obtained by reacting propanediimidates of the formula II R.sup.1 --X--C(.dbd.NH)--CH.sub.2 --C(.dbd.NH)--Y--R.sup.2 (II) or salts thereof with cyanamide in the presence of a base at pH values above pH 7. The process allows the aminopyrimidines to be prepared in a one-pot reaction
Claims10
A process for the preparation of compounds of the formula I ##STR4## in which X and Y are in each case oxygen or sulfur and R.sup.1 and R.sup.2 independently of one another are (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy(C.sub.1 -C.sub.2)alkyl or halo(C.sub.1 -C.sub.4)alkyl, by reacting a propanediimidate of the formula II ##STR5## or a salt thereof with cyanamide (NH.sub.2 --CN) in the presence of a base, which comprises adding the propanediimidate or its salt to a solution of a base and cyanamide in an inert solvent at pH values of above pH 7 to pH 14 and carrying out the reaction.
Dependencies are inferred from the claim text.