Selenomerocyanines and processes for preparation and methods of use and compositions thereof
AssigneeSterling Drug Inc.
InventorsWolfgang H. H. Gunther, Roger Searle
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Abstract
Selenomerocyanines, for example the compound having the structural formula ##STR1## a process for preparation thereof, methods of use thereof as photosensitizers for generation of singlet oxygen, virus inactivation and cancer cell inactivation, and photosensitized silver halide photographic emulsions containing them are disclosed.
Claims17
A compound having the structural formula ##STR16## wherein X is O, S, Se, Te, C(CH.sub.3).sub.2 or NR wherein R is methyl, ethyl, propyl, cyclopropyl, cyclohexyl, phenyl or phenyl substituted by from one to three of methyl, trifluoromethyl, methoxycarbonyl, ethoxycarbonyl, cyano, dimethylamino, methoxy, methylthio, fluoro, chloro, bromo, or iodo;
- Y is alkylene having from two to nine carbon atoms or alkylene having from two to nine carbon atoms interrupted by O, S, NR', CONH or phenylene wherein R' is methyl or phenyl;
- Z.sub.1 and Z.sub.2 are independently H or alkyl having from one to ten carbon atoms;
- m is 0 or 1;
- n is 1, 2 or 3;
- M.sup.+ is pharmaceutically or photographically acceptable cation;
- and
- Ar is a fused aromatic nucleus selected from the group consisting of benzo and naphtho.
Dependencies are inferred from the claim text.