Paramagnetic compounds
AssigneeNycomed Imaging AS
InventorsJo Klaveness, Pal Rongved, Per Strande
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Abstract
There are provided paramagnetic compounds comprising a paramagnetic metal species chelated by a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a macromolecule, wherein said linker group provides a carbon chain of at least 2 atoms between said amide group and said ester group. The novel compounds are particularly suitable as contrast agents, e.g. in magnetic resonance imaging.
Claims18
A paramagnetic compound comprising a paramagnetic metal species chelated by a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a macromolecule selected from the group consisting of polymeric and polymerised carbohydrates and polymerised sugar alcohols, and physiologically tolerable derivatives thereof, wherein said linker group provides a carbon chain of from 2 to 11 atoms between said amide group and said ester group.
A macromolecular chelating compound comprising a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a macromolecule selected from the group consisting of polymeric and polymerised carbohydrates and polymerised sugar alcohols, and physiologically tolerable derivatives thereof, wherein said linker group provides a carbon chain of from 2 to 11 atoms between said amide group and said ester group, or a salt of metal chelate thereof.
Dependencies are inferred from the claim text.