Stabilized solutions of psychotropic agents
AssigneeAkzo N.V.
InventorsPetrus J. M. Van Den Oetelaar, Maria M. F. Mentink
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Abstract
Disclosed are stabilized aqueous preparations containing an antidepressant in admixture with a stabilizing compound such as L-methionine, D-methionine, DL-methionine, or mixtures thereof. The stabilized preparations display better stability when exposed to light, relatively high temperatures, time, and peroxides resulting in longer shelf-lives. Antidepressants which are stabilized include mirtazapine, mianserin, septiline, and amitriptyline.
Claims7
A stable aqueous preparation comprising:
- a stabilizer selected from the group consisting of L-methionine, D-methionine, DL-methionine and mixtures thereof in admixture with water and a therapeutically useful concentration of at least one tricyclic nitrogen heterocycle antidepressant capable of stabilization by the selected stabilizer, wherein the stabilizer is present in a concentration sufficient to stabilize the tricyclic nitrogen heterocycle.
A method of stabilizing an aqueous preparation of amitriptyline comprising:
- dissolving into said aqueous preparation a sufficient amount of L-methionine, D-methionine, DL-methionine, or mixtures thereof to stabilize the heterocycle in aqueous solution.
A stabilized aqueous solution comprising, in admixture, amitriptyline in an amount of about 1 to about 5 milligrams per milliliter of aqueous solution, and a sufficient amount of L-methionine, D-methionine, DL-methionine or mixtures thereof to stabilize said heterocycle in aqueous solution.
Dependencies are inferred from the claim text.