Vinyl Glycine derivatives for memory and learning enhancement or treatment of a cognitive disorder
AssigneeG. D. Searle & Co.
InventorsAlex A. Cordi, Joseph B. Monahan, Robert M. Williams
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Abstract
A class of vinyl glycine derivatives is described for use in memory and learning enhancement or for treatment of a cognitive disorder. The vinyl glycine derivatives of particular interest are compounds of Formula I wherein the double bond is in trans configuration, R.sup.1 is lower alkyl, R.sup.2 is hydrido, R.sup.3 is amino and X is hydroxymethyl. ##STR1##
Claims5
A method to improve cognitive function or to treat cognitive dysfunction by administering to a subject a therapeutically-effective amount of a vinyl glycine derivative or a prodrug thereof, selected from compounds and their pharmaceutically-acceptable salts, of the group consisting of
- trans-L-2-amino-pent-3-enoic acid;
- trans-D-2-amino-pent-3-enoic acid;
- trans-L-2-amino-hept-3-enoic acid;
- trans-D-2-amino-hept-3-enoic acid;
- trans-L-2-amino-dec-3-enoic acid;
- trans-D-2-amino-dec-3-enoic acid;
- trans-D-2-amino-6-hydroxy-hex-3-enoic acid;
- and
- trans-L-2-amino-6-hydroxy-hex-3-enoic acid.
Dependencies are inferred from the claim text.