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US 5,208,258 AGranted
Antihypercholesterolemic compounds and synthesis thereof
AssigneeThe Regents of the University of California
InventorsClayton H. Heathcock, Terry J. Rosen
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Abstract
A method of preparing compactin and mevinolin, ketoacid, enone, and glutarate analogs thereof, and related compounds. The compounds are prepared in substantially enantiomerically pure form using a structurally convergent synthesis. Total syntheses of (+)-compactin, (+)-mevinolin and related compounds are provided. Novel compounds are identified, several of which show significant anti-hypercholesterolemic activity.
Claims5
A method of treating hypercholesterolemia, comprising:
- administering a pharmacologically acceptable dose of a compound selected from the group consisting of:
- ##STR19##
Dependencies are inferred from the claim text.