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US 5,208,255 AGranted
Thioester enantiomeric compounds and their therapeutic uses
AssigneeSociete Civile Bioprojet
InventorsPierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
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Abstract
The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Claims6
An enantiomer (S) compound having the formula ##STR4##
Dependencies are inferred from the claim text.