3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion
AssigneeWarner-Lambert Company
InventorsDiane H. Boschelli, David T. Connor, Clifford D. Wright
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Abstract
3-Alkyloxy-, aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of preparation are also described.
Claims2
A method of treating diseases mediated by inhibiting the adhesion of leukocytes to endothelial cells comprising administering to a host in need thereof an effective amount in unit dosage form of a compound of the formula ##STR10## wherein R.sub.1 is lower alkyl, phenyl, or benzyl;
- R.sub.2 is hydrogen, lower alkyl, phenyl, benzyl, thiophene, (CH.sub.2).sub.m Q, or phenyl, benzyl, or thiophene substituted with (CH.sub.2).sub.m Q;
- n is an integer from 0 to 2;
- m is an integer from 0 to 6;
- Q is CO.sub.2 R.sub.7 where R.sub.7 is hydrogen or lower alkyl;
- and
- R.sub.3, R.sub.4, R.sub.5, R.sub.6 are independently hydrogen, hydroxy, nitro, amino, lower alkyl, and lower alkoxy, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.