Method of selectively inhibiting calcium-independent myocardial phospholipase A2
AssigneeWashington University
InventorRandy H. Weiss
Life of this patent
Estimating the term…
Abstract
Inhibition of calcium-independent myocardial phospholipase A.sub.2 is shown for compounds of the formula: ##STR1## wherein R and R.sup.1 independently represent hydrogen and halogen, alkyl, alkenyl and alkynyl radicals; R.sup.2 represents aryl, aryloxy, and heteroaryl radicals; and X is 1 or 2.
Claims15
A method for treating a mammalian patient susceptible to cardiac injury, including ischemia and related infarction, from the activity of calcium-independent PLA.sub.2 which comprises administering to said patient an effective inhibitory amount of a compound which selectively inhibits calcium-independent PLA.sub.2 said compound represented by the formula ##STR5## wherein R and R.sup.1 independently represent hydrogen and radicals selected from the group consisting of halogen and alkyl, alkenyl, and alkynyl radicals;
- R.sup.2 represents radicals selected from the group consisting of aryl, aryloxy, and heteroaryl radicals selected from aromatic monocyclic, bicyclic or tricyclic heterocycles containing one or more heteroatoms;
- and x represents 1 or 2.
Dependencies are inferred from the claim text.