5-isoquinolinesulfonamides

A compound selected from those of formula (I):

• ##STR18## in which:
• n is 0 or 1 to 4 inclusive,
• m and p are 1 to 4 inclusive, it being understood that the sum m+p is 2, 3, 4 or 5,
• r is 1 to 6 inclusive,
• R.sub.1 represents hydrogen, chlorine, or hydroxy,
• R.sub.2 represents hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, lower cycloalkylalkyl, phenyl, or phenyl loweralkyl,
• X, Y or Z, which are identical or different, represent hydrogen, halogen, or a group chosen from lower alkyl, lower alkoxy, nitro, amino, cyano, acetamido, carboxamido, or X and Y, or Y and Z, together form, with the 2 carbon atoms of the phenyl nucleus carrying them, a furan, dihydrofuran, or benzene ring,
• U represents a single bond, oxygen, sulfur, or a group chosen from:
• carbonyl, sulfinyl, sulfonyl, --NH--CO--, --CO--NH--, or --O--(CH.sub.2).sub.r' --O--, with r' meaning 2 or 3, --(CH.sub.2).sub.r" --O--(CH.sub.2).sub.r"' -- with r" and r"' meaning 1 or 2, and ##STR19## where R.sub.3 represents:
• - hydrogen,
• - formyl,
• - --A, --CO--A, or --CO--O--A, with A meaning lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, or cycloalkylloweralkyl,
• - --(CH.sub.2).sub.q -phenyl or substituted --(CH.sub.2).sub.q -- phenyl, with q meaning 0 or 1 to 4 inclusive,
• - --CO--phenyl or substituted --CO--phenyl,
• - --CO--O--phenyl or substituted --CO--O--phenyl,
• - --CO--NR.sub.4 R.sub.5
• where
• R.sub.4 and R.sub.5 :
• - which are identical or different, represent hydrogen or a group chosen from lower alkyl, lower alkenyl, lower alkynyl, phenyl or pheny, loweralkyl,
• - or form with the nitrogen atom carrying them a saturated ring with 4 to 7 members, 3 to 6 of which are carbon atoms,
• it being understood that the term "substituted" which applies to the groups --(CH.sub.2).sub.q --phenyl, --CO--phenyl, or --CO--O--phenyl means that these groups may be substituted by one or more radicals chosen from:
• lower alkyl, lower alkoxy, hydroxyl, a halogen atom, and trifluoromethyl,
• it being understood that the terms "lower alkyl" and "lower alkoxy" mean linear or branched saturated carbon groups having 1 to 6 carbon atoms, inclusive,
• that the terms "lower alkenyl" and "lower alkynyl" denote linear or branched unsaturated groups having 2 to 6 carbon atoms, inclusive,
• - that the term "cycloalkyl" denotes a saturated carbon ring having 3 to 8 members, inclusive,
• the optical isomers thereof which may exist, as well as, where appropriate, its addition salts with a pharmaceutically-acceptable acid.