8-substituted purines as selective adenosine receptor agents
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsNorton P. Peet, Nelsen L. Lentz, Mark W. Dudley
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Abstract
The present invention relates to certain novel 8-substituted purines as selective A.sub.1 -adenosine receptor antagonists which are useful in the treatment of patients suffering from Alzheimer's disease, congestive heart failure or pulmonary bronchoconstriction.
Claims13
A compound of the formula ##STR36## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a C.sub.1 -C.sub.4 alkyl,
- m is an integer 0, 1 or 2,
- A is O or S,
- n is an integer 1, 2 or 3, and
- R.sub.4 is H or a C.sub.1 -C.sub.4 alkyl.
A compound of the formula ##STR37## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a C.sub.1 -C.sub.4 alkyl,
- m is an integer 0, 1 or 2,
- A is O or S,
- n is an integer 1, 2 or 3,
- Y is --NH(CH.sub.2).sub.p NH--,
- p is an integer 2, 3 or 4
- Z is a radical of the formula ##STR38## q is an integer 0, 1, 2 or 3, and R.sub.5 is a radical selected each time taken from the group consisting of H, CH.sub.3, --CH(CH.sub.3).sub.2, --CH(CH.sub.3)CH.sub.2 CH.sub.3, --CH.sub.2 CH(CH.sub.3).sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 N.dbd.C(NH.sub.2).sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 N.dbd.C(NH.sub.2).sub.2, ##STR39##
A compound of the formula ##STR40## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a C.sub.1 -C.sub.4 alkyl,
- m is an integer 0, 1 or 2,
- A is O or S,
- n is an integer 1, 2 or 3,
- Z is a radical of the formula ##STR41## q is an integer 1, 2 or 3, and R.sub.5 is a radical selected each time taken from the group consisting of H, CH.sub.3, --CH(CH.sub.3).sub.2, --CH(CH.sub.3)CH.sub.2 CH.sub.3, --CH.sub.2 CH(CH.sub.3).sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 N.dbd.C(NH.sub.2).sub.2, --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 N.dbd.C(NH.sub.2).sub.2, ##STR42##
Dependencies are inferred from the claim text.