N-(acylaminomethyl)glutaryl amino acids and use

Abstract

Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino; R.sup.2 is H or hydroxy; R.sup.4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R.sup.6 is H or R.sup.7 --(CH.sub.2).sub.3 --, wherein R.sup.7 is amino or (aryllower alkoxy)carbonylamino; Q is --C(O)-- or --SO.sub.2 --; Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of the formula ##STR2## wherein A is a bond, --N(R.sup.5)--, or --O--; and R.sup.5 is H or lower alkyl; B is H or Z--(CH.sub.2).sub.m -- Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, 1-pyrrolidino or 1-piperidino; m=1,2,3,4 or 5; and n=1,2 or 3; or or a pharmaceutically acceptable addition salt thereof; useful in the treatment of cardiovascular disorders, are disclosed.

Dependencies are inferred from the claim text.