Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsLarry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
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Abstract
There are disclosed anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component in the anti-hypertensive compositions is a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from straight chain and branched chain C.sub.1 -C.sub.12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl group; or R.sub.1 and R.sub.2 together with the nitrogen atom they are bonded to form a heterocyclic ring; M.sup.+X is a pharmaceutically acceptable cation, wherein x is the valence of the cation.
Claims8
An injectable pharmaceutical composition comprising an effective amount of a compound of the Formula:
- ##STR9## wherein R.sub.1 and R.sub.2 together with the nitrogen atom are bonded to form a heterocyclic group of the Formula ##STR10## wherein Z is 1 to 5, M.sup.+X is a pharmaceutically acceptable cation, and x is the valence of the cation;
- and a pharmaceutically acceptable sterile carrier.
A method of treating a cardiovascular disorder in a mammal in need of such treatment, the method comprising lowering the blood pressure of the mammal by administering to the mammal a blood pressure lowering effective amount of a compound of the formula:
- ##STR11## wherein R.sub.1 and R.sub.2 together with the nitrogen atom are bonded to form a heterocyclic ring of the formula ##STR12## wherein Z is 1 to 5, M.sup.+X is a pharmaceutically acceptable cation, and x is the valence of the cation.
Dependencies are inferred from the claim text.