Piperidine compounds and their preparation and use
AssigneeNovo Nordisk A/S
InventorsPalle Jakobsen, Jorgen Dreger
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Abstract
Novel piperidine compounds having the formula ##STR1## wherein the symbols have the same meanings as set forth in the specification, and salts thereof with a pharmaceutically acceptable acid, are disclosed. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.
Claims10
A method of treating anoxia, ischemia, migraine, epilepsy or head injury, which comprises the step of administering to the mammal an effective calcium-uptake-inhibitory amount of a piperidine compound selected from those having the Formula I ##STR23## wherein R.sup.3 is 3,4-methylenedioxyphenyl, phenyl, or naphthyl, which are optionally substituted with one or more halogen, C.sub.1-6 -alkoxy, phenoxy, cyano, mono or poly halogenated C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.1-6 -alkyl, or C.sub.3-5 -alkylene,
- R.sup.1 is C.sub.1-8 -alkyl substituted with piperidino, morpholino, thiomorpholino, dioxolanyl, or tetrahydrofuranyl, wherein the heterocyclic ring is optionally substituted with C.sub.1-6 -alkyl,
- X is hydrogen, halogen, trifluoromethyl, hydroxy, cyano, or C.sub.1-8 -alkoxy,
- Y is O or S;
- and a pharmaceutically-acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.