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US 5,208,223 AGranted
Phosphocholine derivative inhibitors of phospholipase A.sub.2
AssigneeAmerican Cyanamid Company
InventorsAllan Wissner, Robert E. Schaub, Kenneth E. Green, Philip R. Hamann
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Abstract
Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.
Claims6
A compound, including the individual R and S enantiomer and the racemic mixture, represented by the formula:
- ##STR31## wherein:
- A) n is an integer from 2 to 6;
- B) R is selected from the group consisting of C.sub.1 -C.sub.4 alkyl;
- and
- C) Q is ##STR32## and W is hydrogen or hydroxyl, Z is CH.sub.2 --OX wherein R.sup.1 and X are selected from the group consisting of C.sub.1 -C.sub.24 alkyl.
2 more elements
A compound, including the individual R and S enantiomer and the racemic mixture, represented by the formula:
- ##STR33## wherein:
- A) n is an integer from 2 to 6;
- B) R is selected from the group consisting of C.sub.1 -C.sub.4 alkyl;
- and
- C) Z is --CH.sub.2 --O--X wherein R.sup.1 and X are selected from the group consisting of C.sub.1 -C.sub.24 alkyl.
2 more elements
Dependencies are inferred from the claim text.