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US 5,208,220 AGranted
Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
AssigneeMagainin Pharmaceuticals Inc.
InventorBarry Berkowitz
Life of this patent
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Abstract
A composition comprising at least one biologically active amphiphilic peptide or protein, said peptide or protein being an ion channel-forming peptide or protein, and an antibiotic which inhibits DNA gyrase. The biologically active amphiphilic peptide and the antibiotic which inhibits DNA gyrase may be administered in amounts effective to inhibit growth of a target cell such as a bacterium.
Claims63
A process of inhibiting growth of a microbe in a host, comprising:
- administering to a host at least one biologically active amphiphilic peptide and/or biologically active protein, said biologically active peptide or protein being an ion channel-forming peptide or protein;
- and
- an antibiotic which inhibits DNA gyrase, said components being administered in a combined amount effective to inhibit growth of a microbe in a host.
A composition, comprising:
- (a) at least one biologically active amphiphilic peptide and/or biologically active protein, said peptide or protein being an ion channel-forming peptide or protein;
- (b) an antibiotic which inhibits DNA gyrase;
- and
- (c) an acceptable pharmaceutical carrier, wherein said components (a) and (b) are present in a combined amount effective to inhibit growth of a microbe.
1 more element
A process of inhibiting growth of a microbe in a host, comprising:
- administering to a host at least one biologically active amphiphilic peptide selected from the group consisting of:
- (a) a magainin peptide;
- (b) a PGLa peptide;
- (c) an XPF peptide;
- (d) a CPF peptide;
- (e) a cecropin;
- (f) a sarcotoxin;
- (g) a basic polypeptide having at least sixteen amino acids, wherein said basic polypeptide includes at least eight hydrophobic amino acids and at least eight hydrophilic amino acids;
- (h) a peptide including the following basic structure X.sub.40 :
- (R.sub.41 --R.sub.42 --R.sub.42 --R.sub.43 --R.sub.41 --R.sub.42 --R.sub.42).sub.n,
- wherein R.sub.41 is a basic hydrophilic amino acid, R.sub.42 is a hydrophobic amino acid, R.sub.43 is a neutral hydrophilic amino acid or hydrophobic amino acid, and n is from 2 to 5;
- and
- (i) a peptide including the following basic structure X.sub.50 :
- R.sub.41 --R.sub.42 --R.sub.42 --R.sub.43 --R.sub.41 --R.sub.42 --R.sub.42 --R.sub.41 --R.sub.42 --R.sub.42 --R.sub.42 --R.sub.41 --R.sub.41 --R.sub.42,
- wherein R.sub.41 is a basic hydrophilic amino acid, R.sub.42 is a hydrophobic amino acid, R.sub.43 is a neutral hydrophilic amino acid or a hydrophobic amino acid, and an antibiotic which inhibits DNA gyrase, said biologically active amphiphilic peptide and said antibiotic which inhibits DNA gyrase being administered in a combined amount effective to inhibit growth of a microbe in a host.
12 more elements
A composition comprising:
- (a) at least one biologically active amphiphilic peptide selected form the group consisting of:
- (i) a magnesium peptide;
- (ii) a PGLa peptide;
- (iii) an XPF peptide;
- (iv) a CPF peptide;
- (v) a cecropin;
- (vi) a sarcotoxin;
- (vii) a basic polypeptide having at least sixteen amino acids, wherein said basic polypeptide includes at least eight hydrophobic amino acids and at least eight hydrophilic amino acids;
- (viii) a peptide including the following basic structure X.sub.40 :
- (R.sub.41 --R.sub.42 --R.sub.42 --R.sub.43 --R.sub.41 --R.sub.42 --R.sub.42).sub.n,
- wherein R.sub.41 is a basic hydrophilic amino acid, R.sub.42 is a hydrophobic amino acid, R.sub.43 is a neutral hydrophilic amino acid or a hydrophobic amino acid, and n is from 2 to 5;
- and
- (ix) a peptide which includes the following basic structure X.sub.50 :
- R.sub.41 --R.sub.42 --R.sub.42 --R.sub.43 --R.sub.41 --R.sub.42 --R.sub.42 --R.sub.41 --R.sub.42 --R.sub.42 --R.sub.42 --R.sub.41 --R.sub.42 --R.sub.42,
- wherein R.sub.41 is a basic hydrophilic amino acid, R.sub.42 is a hydrophobic amino acid, R.sub.43 is a neutral hydrophilic amino acid or a hydrophobic amino acid, and
- (b) an antibiotic which inhibits DNA gyrase;
- and (c) an acceptable pharmaceutical carrier, wherein said components (a) and (b) are present in a combined amount effective to inhibit growth of a microbe in a host.
14 more elements
Dependencies are inferred from the claim text.