T cell growth factor glycoproteins
AssigneeLudwig Institute for Cancer Research
InventorsJacques Van Snick, Catherine Uyttenhove, Richard J. Simpson
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Abstract
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof and antibodies thereto. The present invention also contemplates a method for inducing the proliferation of helper T cells. The helper T cell growth factor contemplated herein is useful in the stimulation of specific cells in the immune system.
Claims6
An isolated biologically pure, mammalian T cell growth factor molecule which is a single chain glycoprotein having a molecular weight of from about 30 KDa to about 40 KDa and which supports interleukin-2 and interleukin-4 independent growth of helper T cells.
Dependencies are inferred from the claim text.