Oxidation stable detergent enzymes
AssigneeNovo Nordisk A/S
InventorsLene M. Bech, Sven Branner, Klaus Breddam, Hanne Groen
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Abstract
Novel chemically modified detergent enzymes are provided, wherein one or more methionines have been mutated into cysteines, said cysteines subsequently being chemically modified in order to confer the enzyme improved stability towards oxidative agents. A novel process for stabilizing detergent enzymes against oxidation is also provided. Furthermore, there are provided detergent compositions comprising these novel oxidation stable detergent enzymes.
Claims12
A modified enzyme, wherein one or more methionine residues of a detergent enzyme are replaced by cysteine having an HS-group, wherein said cysteine residue(s) are further modified by replacing the hydrogen atom of the HS-group with a group of formula R.sup.1 S--, wherein R.sup.1 is C.sub.1-6 -alkyl.
A modified enzyme, wherein a subtilisin is modified by replacing the methionine residue in position 222 with cysteine having an HS-group, wherein the cysteine residue is further modified by replacing the hydrogen atom of the HS-group with a group of the formula R.sup.1 S--, wherein R.sup.1 is C.sub.1-6 -alkyl.
Dependencies are inferred from the claim text.