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US 5,208,037 AGranted
Dosage forms comprising polymers comprising different molecular weights
AssigneeAlza Corporation
InventorsJeri D. Wright, Brian L. Barclay, David R. Swanson
Life of this patent
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Abstract
A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weigh carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.
Claims7
A method for administering a drug to the gastrointestinal tract of a patient, which method comprises,
- (a) admitting a dosage form orally into a patient, said dosage form comprising:
- (1) a first layer comprising 10 ng to 750 mg of drug;
- (2) a second layer for pushing the first layer from the dosage form;
- (3) a wall surrounding the first and second layers, the wall comprising at least in part, a composition permeable to the passage of fluid;
- (4) an exit passageway in the wall for delivering the drug from the dosage form to the patient;
- and wherein said,
- (5) first layer comprises an alkali carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- and said,
- (6) second layer comprises an alkali carboxymethylcellulose comprising a molecular weight greater than 300,000;
- and wherein the dosage form when in use is characterized by said:
- (7) first layer possessing an initial flow-resistant that is changed in the presence of imbibed fluid into a dispensable aqueous drug layer;
- and said:
- (8) second layer pushing the first layer through the exit passageway, with each alkali carboxymethylcellulose maintaining its original separate identities and functions;
- thereby,
- (b) administering the drug by the first and second layers cooperating to administer substantially all the drug to the patient over time.
12 more elements
The method for administering a drug to the gastrointestinal tract of a patient wherein the method comprises:
- (a) admitting a dosage form orally into the patient, said dosage form comprising:
- (1) a first composition comprising 10 ng to 750 mg of a drug selected from the group consisting of nifedipine, verapamil, diltiazem, bepridil, nicardipine, nitredipine, isradipine, and niludepine;
- (2) a second composition for pushing the first composition from the dosage form;
- (3) a wall surrounding the first and second compositions, the wall comprising at least in part, a composition permeable to the passage of fluid;
- (4) an exit passageway in the wall for delivering the drug from the dosage form to the patient;
- and wherein said,
- (5) first composition comprises a member selected from the group consisting of a potassium and sodium carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- and said,
- (6) second composition comprises a member selected from the group consisting of a potassium and sodium carboxymethylcellulose comprising a molecular weight greater than 300,000;
- and,
- (b) administering the drug by the first and second composition cooperating to administer substantially all the drug to the patient over time.
8 more elements
Dependencies are inferred from the claim text.