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US 5,208,015 AGranted
Topical anti-fungal agents having anti-inflammatory activity
AssigneeBristol-Myers Squibb Company
InventorsHemanshu S. Shah, Cheng-Der Yu, John Gibson
Life of this patent
Estimating the term…
Abstract
The certain imidazoles have been found to exhibit anti-inflammatory as well as antifungal activity.
Claims11
A composition useful for the topical treatment of inflammations associated with fungal infections of the skin or scalp consisting essentially of:
- (a) about 0.1 to about 10% of at least one compound of formula I or a pharmaceutically acceptable derivative thereof:
- ##STR3## wherein x =O or S;
- n =1, 2 or 3;
- and
- (b) a pharmaceutically acceptable carrier therefor, wherein the carrier contains a lower alcohol, a trihydroxy alcohol, a dihydroxy alcohol and water.
2 more elements
A process for treating an inflammatory condition associated with a fungal infection of the skin or scalp which comprises the step of:
- contacting the area to be treated with a composition consisting essentially of:
- (a) about 0.1 to about 10% of at least one compound of formula I or a pharmaceutically acceptable derivative thereof:
- ##STR4## wherein X =O or S and
- n =1, 2 or 3;
- and
- (b) an alcoholic pharmaceutically acceptable carrier therefor.
3 more elements
A composition useful for the topical treatment of inflammations associated with fungal infections of the skin or scalp consisting essentially of:
- (a) about 0.1 to about 10% of at least one compound of formula I or a pharmaceutically acceptable derivative thereof:
- ##STR5## wherein X =O or S;
- n =1,2 or 3;
- and (b) a pharmaceutically acceptable carrier therefor, wherein the carrier contains a lower alcohol, a trihydroxy alcohol, a dihydroxy alcohol and water;
- and (c) from about 0 to about 50% of emollient(s) and about 0.1 to about 5% of a gelling agent and about 0 to about 5% of preservative(s).
2 more elements
Dependencies are inferred from the claim text.